Confident quantitation with triple quadrupole LC-MS systems
From addressing complexities of molecules and matrices, to ensuring ease-of-use while satisfying regulatory requirements—today’s challenges in targeted quantitation involve more than just measuring concentrations of target analytes. Achieve ultimate confidence in your data quality with a robust, sensitive, reproducible, and reliable targeted quantitation method using our new liquid chromatography mass spectrometry (LC/MS) workflow solutions. Our TSQ Triple Quadrupole MS systems also come with a Three Year Factory Warranty so you can gain peace of mind.
- TSQ Quantum Access MAX Triple Quadrupole Mass Spectrometer
- Clinical Mass Spectrometry
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For today and what's next
TSQ Altis Triple Quadrupole Mass Spectrometer
Ultimate sensitivity & selectivity to meet tomorrow’s standards today
For everyday excellence
TSQ Quantis Triple Quadrupole
Mass Spectrometer
Everyday quantitation workhorse to meet today’s standards
For a new level of confidence
TSQ Fortis Triple Quadrupole Mass Spectrometer
Quality data across workflows for users at all levels of expertise
Triple quadrupole LC-MS system product comparison
Different applications require different levels of system sensitivity, resolution, and speed. In this table, we compare different TSQ triple quadrupole systems in order to showcase which ones are most relevant to your laboratory's needs. For more information on these systems, click on our Smartnote: Transitioning to Confident Quantitation – in search of a better tomorrow
| Triple Quad Product Comparison |  Fortis |
 Endura |
 Quantis |
 Altis |
|
| Sensitivity | +++ | +++ | ++++ | +++++ | |
| Resolution | ++ | ++ | ++ | +++ | |
| Scan Speed | ++++ | +++ | ++++ | ++++ | |
| Applications across multiple matrices | |||||
| Targeted quantitation in Proteomics | No | Yes | Yes | Yes | |
| Peptide and protein quantitation (Biopharma) | No | Yes | Yes | Yes | |
| Small molecule quantitation (Pharma, Clinical Research) | Yes | Yes | Yes | Yes | |
| Small molecule mixture quantitation (Environmental Safety, Food Safety, Forensic Toxicology, Pharma) | Yes | Yes | Yes | Yes | |
| Analysis and targeted quantitation of trace impurities (Impurity Quantitation) | Yes | Yes | Yes | Yes | |
| Targeted quantitation in Omics (metabolomics, lipidomics) | Yes | Yes | Yes | Yes | |
| Critical Features | |||||
| MRM for reliable identification | Yes | Yes | Yes | Yes | |
| Multiple Source Compatibility | Yes | Yes | Yes | Yes | |
| High Resolution SRM: for increased selectivity and sensitivity for analytes or multiple analytes in complex matrices | ++ | ++ | ++ | +++ | |
| Segmented quadrupoles for increased ion efficiency | Yes | No | Yes | Yes | |
| Neutral blocker for increased robustness | Yes | Yes | Yes | Yes | |
| Increased dynodes in detector for increased lifetime and better linear dynamic range | Yes | No | Yes | Yes | |
| APCI compatible with HESI source | Yes | No | Yes | Yes | |
| Polarity Switching: Fast switching with stabilization enable faster quantitation assays for every molecule type | + | + | + | + | |
| System Remote Monitoring | Yes | Yes | Yes | Yes | |
| Assist with 21 CFR Part 11 Compliance (appropriate software) | Yes. With LCQUAN™ Software | Yes. With LCQUAN™ Software | Yes. With LCQUAN™ Software | Yes. With LCQUAN™ Software | |
| Instrument IQ/OQ assist | Yes | Yes | Yes | Yes | |
| Thermo Fisher Cloud: Access, process, review data whenever you like, from wherever you are | No | Yes | Yes | Yes | |
| Wi-Fi Connectivity: Access your data, Check your assay performance remotely | Yes | Yes | Yes | Yes | |
| Size | 27x30x33 (in) | 27x30x33 (in) | 27x30x33 (in) | 27x30x33 (in) | |
| IVD Platform | No | Available in certain countries | No | No | |
| Compatible separation technologies | UltiMate, Vanquish, Multiplexing, Capillary LC, Other vendors | UltiMate, Vanquish, Other vendors, IC, Multiplexing, Capillary LC, NanoLC | UltiMate, Vanquish, Other vendors, IC, Multiplexing, Capillary LC, NanoLC | UltiMate, Vanquish, Other vendors, IC, Multiplexing, Capillary LC, NanoLC | |
| Compatible Software? | Xcalibur, TraceFinder, Chromeleon | Xcalibur, TraceFinder, Chromeleon | Xcalibur, TraceFinder, Chromeleon | Xcalibur, TraceFinder, Chromeleon | |
| Library availability | Yes | Yes | Yes | Yes | |
Common applications of triple quadrupole technology
To perform quantitation assays with confidence, you need a liquid chromatography mass spectrometry (LCMS) workflow solution that is relevant to your laboratory’s goals. These workflow solutions are adapted to specific applications, including clinical research, environmental and food safety, forensic toxicology, and pharma/biopharma.
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Tomorrow's Quantitation Compendium
Developing robust quantitation assays is possible with both Triple Quadrupole and Orbitrap-based High- resolution MS instruments. Both technologies enable confident quantitation in a variety of sample types.
LC-MS webinar series
Expand your application knowledge
Our LC-MS on-demand webinar series expands your application knowledge for pharma, biopharma, environmental, omics, food, forensics and clinical research and more. Learn how the latest high-performance mass spectrometry solutions can enable your laboratory to solve your most pressing analytical challenges, regardless of sample type.
40 year anniversary of Thermo Scientific development and success of triple quadrupole mass spectrometers
